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KMID : 0620920100420120805
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Experimental & Molecular Medicine
2010 Volume.42 No. 12 p.805 ~ p.810
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Nuclear factor of activated T cells negatively regulates expression of the tumor necrosis factor receptor-related 2 gene in T cells
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Kim Woon-Ki
Sul Ok-Ju
Kwak Jung-Sook
Hur Hye-Young
Latour Anne M.
Koller Beverly H.
Kwon Byoung-S.
Jeong Choon-Soo
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Abstract
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Tumor necrosis factor receptor-related 2 (TR2, HVEM or TNFRSF-14) plays an important role in immune responses, however, the mechanisms regulating its expression are unclear. To understand the control of TR2 gene expression, we studied the upstream region of the gene. Gel supershift assays revealed inducible binding of nuclear factor of activated T cells (NFAT) to a putative NFAT site within the TR2 promoter. Furthermore, cotransfection of a dominant negative NFAT construct, or siRNA for NFAT, resulted in increased expression of a TR2 reporter gene. Our findings demonstrate that NFAT negatively regulates TR2 expression in activated T cells.
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KEYWORD
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gene expression regulation, NFATC transcription promoter regions, genetic, T lymphocytes, tumor necrosis factor ligand superfamily member
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